Solution structure of the antiapoptotic protein bcl-2
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چکیده
منابع مشابه
Solution structure of the antiapoptotic protein bcl-2.
The structures of two isoforms of Bcl-2 that differ by two amino acids have been determined by NMR spectroscopy. Because wild-type Bcl-2 behaved poorly in solution, the structures were determined by using Bcl-2/Bcl-x(L) chimeras in which part of the putative unstructured loop of Bcl-2 was replaced with a shortened loop from Bcl-x(L). These chimeric proteins have a low pI compared with the wild-...
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Apoptosis, also known as programmed cell death or physiologic cell death, plays diverse roles in embryogenesis and normal homeostasis as well as in oncogenesis. Apoptotic processes are modulated by several geneencoded products, including the Bcl-2 family proteins, which have inhibitory or stimulatory effects.1 Bcl-2 derives its name from B-cell lymphoma 2, as it is the second member of a range ...
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Background and aims: Pancreatic cancer remains a devastating diagnosis with only limited therapeutic options. Specific inhibition of expression of target genes has become possible using small interfering (si) RNAs. We therefore investigated how far siRNA specific for bcl-2 may serve as a therapeutic option for pancreatic cancer in vitro and in vivo. Methods: siRNAs targeting two different regio...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2001
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.041619798